Home › Researcher directory › Khaled Hamden
Khaled Hamden
Affiliation : University of Sfax · University of Monastir
- 93Publications (affiliation in Tunisia)
- 107Total publications
- 3638Citations
- 39h-index
Research profile
Khaled Hamden has 93 indexed publications (2006–2026). Their work appears mainly in “Archives of Physiology and Biochemistry”, “International Journal of Biological Macromolecules” and “Journal of Physiology and Biochemistry”. Their most cited article, “Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats” (2012), has been cited 201 times. 15 of these publications date from the last three years of activity. Their work is co-authored with at least 12 researchers, including institutions in Saudi Arabia, France.
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Create my free profile Add my publicationsResearch areas
- Natural Antidiabetic Agents Studies
- Medicinal Plant Research
- Sperm and Testicular Function
- Pancreatic function and diabetes
- Antioxidant Activity and Oxidative Stress
Publications (93)
- Structural, optical, and biological investigations of a new hybrid compound Bis(1,8-diazabicyclo[5.4.0]undec‑7-enium) tetrachloridozincate(II)
- C-phycocyanin protects against obesity-associated type 2 diabetes-induced male fertility dysfunction via key enzyme regulation
- Comparative Study of Sulfated Polysaccharides From Ulva Lactuca Grown in Tunisia and Morocco: in Vitro Antioxidant Activity and in Vivo Anti‐Inflammatory and Anti‐Ulcer Effects
- Structure–biological activity relationships in a zinc( ii ) pyrazole halide complex [ZnCl 2 (η 1 -4BrPz) 2 ] via noncovalent interactions, molecular docking, and antimicrobial studies
- Novel triazole-tethered thiazol-4(5H)-one hybrids as potential therapeutics for obesity and type 2 diabetes: in vitro, in vivo, and in silico evaluations
- Potential protective effect of bacterial prodigiosin on the pancreas in diabetic rats: alleviating inflammation, oxidative stress, and histological damage with antidiabetic properties
- Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential
- Design of a new palladium( ii ) halide complex as a bio-active material: synthesis, physico-chemical studies, DFT-computations and evaluation of anti-inflammatory, antioxidant and anti-gastric damage activities
- Fructooligosaccharides from Cynoglossum tubiflorus: Effect of the molecular size on their antidiabetic activity in high-fat diet and alloxan induced diabetic rats
- Spirothiazolidine-Derivative on Silver Nanoparticles and Carbon Nanotubes: Evaluation of Antibacterial, Anti-Fungal, Anti-Inflammatory, Antioxidant and Gastroprotective Activities
- WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism
- WITHDRAWN: Spirulina C-phycocyanin: extraction, purification, stabilization, and inhibitory potential of key enzymes rRelated to pancreas inflammation, carbohydrate digestion, and glucose metabolism
- An Investigation of Two Cu (II)‐Based Hybrid Materials: Physico‐Chemical Characterization, Theoretical Calculation and Evaluation of The Inhibitory Activities against Key Enzymes related to Diabetes and Obesity
- Effects of Olea oleaster leaf extract and purified oleuropein on ethanol-induced gastric ulcer in male Wistar rats.
- Retraction notice to “Ephedra alata subsp. alenda (Ephedraceae) leaf extracts: phytochemical screening, anti-diabetic, anti-obesity and anti-toxic activities on diabetic-induced liver-kidney-testes toxicities and inhibition of α-amylase and lipase enzymes” [HLY 8 (2021) e11954]
- Betalain-Enriched Beetroots Exhibit Antiulcer and Anti-inflammatory Potentials
- Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities
- Evaluation of Gastroprotective Effect of Betalain-Rich Ethanol Extract from Opuntia stricta var. Dillenii Employing an In Vivo Rat Model
- The Use of D-Optimal Mixture Design in Optimizing Formulation of a Nutraceutical Hard Candy
- Design, synthesis and biological evaluation of new 1,ω-Bis-(5-alkyl-3-tosyl-1,3,4,2-triazaphospholino)alkanes as in vitro α-amylase and lipase inhibitors
- New spiropyrrolothiazole derivatives bearing an oxazolone moiety as potential antidiabetic agent: Design, synthesis, crystal structure, Hirshfeld surface analysis, ADME and molecular docking studies
- Globularia alypum Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental Diabetic Rats
- RETRACTED: Ephedra alata subsp. alenda (Ephedraceae) leaf extracts: phytochemical screening, anti-diabetic, anti-obesity and anti-toxic activities on diabetic-induced liver-kidney-testes toxicities and inhibition of α-amylase and lipase enzymes
- Diversity-Oriented Synthesis of Spiropyrrolo[1,2- a ]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-Component 1,3-Dipolar Cycloaddition Reactions: In Vitro and in Vivo Evaluation of the Antidiabetic Activity of Rhodanine Analogues
- Antihyperlipidemic, Antihyperglycemic, and Liver Function Protection of Olea europaea var. Meski Stone and Seed Extracts: LC-ESI-HRMS-Based Composition Analysis
- Ephedra alata extracts exerts anti-obesity, anti-hyperglycemia, anti-antipyretic and analgesic effects
- Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors
- Fermented soy milk prepared using kefir grains prevents and ameliorates obesity, type 2 diabetes, hyperlipidemia and Liver-Kidney toxicities in HFFD-rats
- Anti-obesity, anti-hyperglycaemic, anti-antipyretic and analgesic activities of Globularia alypum extracts
- Occurrence of 40 pharmaceutically active compounds in hospital and urban wastewaters and their contribution to Mahdia coastal seawater contamination
- Imipenem toxicity in male reproductive organs as a result of inflammatory microenvironment and oxidative stress in germinal cells
- Phytoestrogens inhibit key-enzymes linked to obesity, type 2 diabetes and liver-kidney toxicity in high fructose-fat diet in mice
- Inhibitory Effect of fermented pectin on key metabolic enzymes associated with diabetes, obesity; and Liver-Kidney tissues toxicities
- Modulatory Effect of an Isolated Triglyceride from Fenugreek Seed Oil on of α-Amylase, Lipase and ACE Activities, Liver-Kidney Functions and Metabolic Disorders of Diabetic Rats
- The cruciferous Diplotaxis simplex: Phytochemistry analysis and its protective effect on liver and kidney toxicities, and lipid profile disorders in alloxan-induced diabetic rats
- Protective and curative effects of Bacillus subtilis SPB1 biosurfactant on high-fat-high-fructose diet induced hyperlipidemia, hypertriglyceridemia and deterioration of liver function in rats
- Evaluation ofBacillus subtilisSPB1 biosurfactant effects on hyperglycemia, angiotensin I-converting enzyme (ACE) activity and kidney function in rats fed on high-fat–high-fructose diet
- Effect of a probiotic Lactobacillus plantarum TN8 strain on trinitrobenzene sulphonic acid‐induced colitis in rats
- Effet de l’administration du biosurfactant de Bacillus subtilis SPB1 sur l’activité de l’enzyme de conversion de l’angiotensine dans le sérum et le cœur des rats rendus obèses par un régime riche en fructose et en graisses de mouton
- Ameliorating effects of goby fish protein hydrolysates on high-fat-high-fructose diet-induced hyperglycemia, oxidative stress and deterioration of kidney function in rats
- Assessment of the antidiabetic and antilipidemic properties of bacillus subtilis spb1 biosurfactant in alloxan‐induced diabetic rats
- Synthesis and Evaluation of New Bis‐1,3,4,2‐triazaphospholinoalkane Derivatives as In Vitro α‐Amylase and Lipase Inhibitors
- In vitro anti-diabetic, anti-obesity and antioxidant proprieties of Juniperus phoenicea L. leaves from Tunisia
- Antioxidative and ACE inhibitory activities of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats
- Corrigendum to "Inhibition of Key Digestive Enzymes Related to Diabetes and Hyperlipidemia and Protection of Liver-Kidney Functions by Trigonelline in Diabetic Rats" [Sci Pharm. 2013; 81: 233–246]
- Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats
- Inhibition of Key Digestive Enzymes-Related to Diabetes and Hyperlipidemia and Protection of Liver-Kidney Functions by Trigonelline in Diabetic Rats
- Antioxidant effect of nondigestible levan and its impact on cardiovascular disease and atherosclerosis
- Experimental diabetes treated with trigonelline: effect on key enzymes related to diabetes and hypertension, β-cell and liver function
- Inhibitory activities ofUlva lactucapolysaccharides on digestive enzymes related to diabetes and obesity
- Lactobacillus plantarum TN627 significantly reduces complications of alloxan-induced diabetes in rats
- Hypoglycemic and hypolipidemic effects of protein hydrolysates from zebra blenny (Salaria basilisca) in alloxan-induced diabetic rats
- Lactobacillus plantarum TN8 exhibits protective effects on lipid, hepatic and renal profiles in obese rat
- Inhibition of carbohydrate and lipid digestive enzymes activities by Zygophyllum album extracts: effect on blood and pancreas inflammatory biomarkers in alloxan-induced diabetic rats
- Synthesis and Evaluation of 1,ω‐Bis(1,2,3,5‐thiatriazol‐5‐yl)alkanes as In Vitro and In Vivo α‐Amylase and Lipase Inhibitors
- Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats
- Inhibitory Activities ofZygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats
- Hypolipidemic effect of diet supplementation with bacterial levan in cholesterol-fed rats
- A new triterpene from olea europea stem with antidiabetic activity
- Antidiabetic activity of levan polysaccharide in alloxan-induced diabetic rats
- Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats
- Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats
- Protective effect of quercetin against oxidative stress caused by dimethoate in human peripheral blood lymphocytes
- In Vivo Prevention of Bladder Urotoxicity
- Inhibitory effect of fenugreek galactomannan on digestive enzymes related to diabetes, hyperlipidemia, and liver-kidney dysfunctions
- Immunomodulatory, β-cell, and neuroprotective actions of fenugreek oil from alloxan-induced diabetes
- Therapeutic effects of soy isoflavones on α-amylase activity, insulin deficiency, liver–kidney function and metabolic disorders in diabetic rats
- Potential protective effect on key steroidogenesis and metabolic enzymes and sperm abnormalities by fenugreek steroids in testis and epididymis of surviving diabetic rats
- Modulatory effect of fenugreek saponins on the activities of intestinal and hepatic disaccharidase and glycogen and liver function of diabetic rats
- Inhibitory action of purified hydroxytyrosol from stored olive mill waste on intestinal disaccharidases and lipase activities and pancreatic toxicity in diabetic rats
- Inhibitory effects of estrogens on digestive enzymes, insulin deficiency, and pancreas toxicity in diabetic rats
- Impairment of Spermatogenesis in Rats by Mercuric Chloride: Involvement of Low 17β-Estradiol Level in Induction of Acute Oxidative Stress
- An in vitro study on reproductive toxicology of Deltamethrin on rat spermatozoa
- Potential protective effect of hydroxytyrosol against glucose-induced toxicity in spermatozoa in vitro
- Hypoglycemic and antioxidant effects of phenolic extracts and purified hydroxytyrosol from olive mill waste in vitro and in rats
- Testicular toxicity in mercuric chloride treated rats: Association with oxidative stress
- 1α,25 Dihydroxyvitamin D3: Therapeutic and Preventive Effects against Oxidative Stress, Hepatic, Pancreatic and Renal Injury in Alloxan-Induced Diabetes in Rats
- Oral administration of Eucalyptus globulus extract reduces the alloxan-induced oxidative stress in rats
- Inhibitory Effect of Estrogens, Phytoestrogens, and Caloric Restriction on Oxidative Stress and Hepato-toxicity in Aged Rats
- Improvement effect of green tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium
- Dietary Nigella sativa and Peganum harmala oils reverses hyperglycaemia, hepatotoxicity, and metabolism in rats
- Inhibitory effects of Zinc on hyperglycaemia and metabolic disorders in the liver of alloxan-induced diabetic rats
- Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: Protective effect of 17β-estradiol
- Combined vitamins (C and E) and insulin improve oxidative stress and pancreatic and hepatic injury in alloxan diabetic rats
- Therapeutic effect of phytoecdysteroids rich extract from Ajuga iva on alloxan induced diabetic rats liver, kidney and pancreas
- Positive effects of Green Tea on hepatic dysfunction, lipid peroxidation and antioxidant defence depletion induced by cadmium
- Protective effects of estrogens and caloric restriction during aging on various rat testis parameters
- Inhibitory effects of 1α, 25dihydroxyvitamin D3 and Ajuga iva extract on oxidative stress, toxicity and hypo-fertility in diabetic rat testes
- Protective effects of Peganum harmala extracts on thiourea-induced diseases in adult male rat.
- Age-related decrease in aromatase and estrogen receptor (ERα and ERβ) expression in rat testes: protective effect of low caloric diets
- Inhibitory effects of 1alfa, 25dihydroxyvitamin D3 and Ajuga iva extract on oxidative stress, toxicity and hypo-fertility in diabetic rat testes
- Protective effect of 17β-estradiol on oxidative stress and liver dysfunction in aged male rats
- P2-167 - Effets du vieillissement et des régimes hypocaloriques sur l’expression des gènes de l’aromatase et des récepteurs aux oestrogènes dans le testicule du rat
Publication venues
- Archives of Physiology and Biochemistry × 6
- International Journal of Biological Macromolecules × 5
- Journal of Physiology and Biochemistry × 4
- HAL × 4
- Journal of Molecular Structure × 3
- Asian Journal of Andrology × 3
Publications per year
- 20264
- 20252
- 20249
- 20235
- 20223
- 20213
- 20203
- 20192
- 20182
- 20172
Collaborations
Partner institutions : Faculty of Sciences of Sfax · Hopital Universitaire Habib Bourguiba · Centre of Biotechnology of Sfax · Institut Supérieur de Biotechnologie de Sfax · Tunis University
Co-authors’ countries : Saudi Arabia · France
Co-authors
- Abdelfattah Elfeki
- Abdelfattah El Feki
- Noureddine Allouche
- Fatma Makni Ayadi
- Kais Mnafgui
- Bassem Jaouadi
- Mohamed Damak A
- Sarra Boudriga
- Mohamed Ali Boujbiha
- Hatem Masmoudi
- Mohamed Tiss
- Amani Toumi
Bibliographic data from OpenAlex (open database).
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