AI & Research

arXiv:2610.27012v1 Announce Type: new Abstract: Reinforcement learning with verifiable rewards (RLVR) trains a language model by sampling responses, scoring them with an automatic verifier, and updating the policy from the resulting rewards. The policy therefore receives direct learning signals only from trajectories that appear in its rollouts. Yet repeated sampling from the same policy can concentrate on similar reasoning paths, leaving useful alternatives unexplored under a fixed rollout budget. We introduce Activation-Space Exploration (ASE), an online method for diversifying training rollouts. By clustering activation differences between correct and incorrect responses to the same problem, ASE builds a structured bank of latent exploration vectors. Different vectors are then applied to subsequent rollouts to explore alternative reasoning paths. On Qwen3-1.7B-Base and Qwen3-8B-Base trained on DAPO-Math-17k, ASE improves average Mean@8 across six mathematical reasoning benchmarks over GRPO by 4.87 and 1.87 percentage points, respectively, under the same rollout budget.

arXiv:2610.27001v1 Announce Type: new Abstract: Drug--target affinity (DTA) prediction plays an important role in computer-aided drug discovery, where reliable computational models can help prioritize compound--protein pairs before experimental validation. A key challenge in DTA prediction is to effectively mine multi-level molecular information from drug structures while accurately modeling the binding-site environment of target proteins. To address these issues, we introduce HierDTA, a hierarchical structure-aware framework for DTA prediction. \textcolor{black}{HierDTA represents each drug as an atom--motif heterogeneous graph and introduces an augmentation module that propagates functional-motif semantics to the corresponding atoms. For proteins, kinase-domain structures are converted into residue interaction graphs. The resulting atom and residue representations are integrated using cross-attention to capture pair-specific relationships, while molecule fingerprints and pretrained ESM-2 embeddings provide complementary global information. Compared with state-of-the-art methods, HierDTA achieves superior performance on the Davis dataset across all metrics and attains the highest \(r_m^2\) of 0.791 on KIBA. It also exhibits strong generalization under cold-start settings, particularly on KIBA, where MSE is reduced by 21.7\% in the unseen-protein scenario. Ablation study and interpretability analysis supported the contributions of the hierarchical augmentation and interaction components.} Case studies further showed that HierDTA provided early enrichment of candidate bioactive compounds. These results indicate that HierDTA is an effective framework for affinity prediction and target-specific virtual screening.

arXiv:2610.27000v1 Announce Type: new Abstract: Deep generative models provide an effective modern solution to alleviating the problem of data scarcity by synthesizing realistic time series. However, despite the considerable progress achieved by existing deep time series generators, two key challenges remain: (1) learning hierarchical representations for heterogeneous temporal patterns; and (2) coordinating the generation process of heterogeneous temporal dynamics. To address these key bottlenecks, in this work, we propose ORBIT, a unified deep generative framework for time series. Specifically, we develop two key components: the Frequency-Hierarchical VQ-VAE (FH-VQ-VAE) and the Frequency-Band Autoregressive Transformer (FBAR). The former learns hierarchical representations by decomposing latent temporal representations into different frequency bands and applying residual quantization with increasing token budgets. The latter establishes a novel low-to-high frequency autoregressive direction, yielding a time series generation process that first constructs global temporal structures and then incrementally incorporates fine-grained temporal details. These compact designs not only disentangle heterogeneous temporal patterns for more effective representation learning but also mitigate potential interference among different temporal dynamics during generation. Extensive experiments on multiple challenging real-world benchmarks demonstrate that ORBIT achieves state-of-the-art overall performance while exhibiting superior inference efficiency compared with advanced baselines.

arXiv:2610.26999v1 Announce Type: new Abstract: Deep learning for radio frequency (RF) signal analysis relies on large annotated datasets, yet synthetic datasets trade physical realism for controllability, while uncontrolled over-theair measurements offer realism but limited reproducibility. We present CorteXforge, a scenario-based framework for generating realistic and reproducible RF datasets on programmable software defined radio (SDR) testbeds. High-level RF scenarios are automatically translated into synchronized experiments executed on the SLICES-RI/CorteXlab platform, producing fully annotated Signal Metadata Format (SIGMF) datasets that capture hardware impairments and propagation effects. We validate CorteXforge through automatic modulation classification using ModForge, an over-the-air (OTA) dataset generated with the framework. Cross-domain experiments reveal a synthetic-to-real performance gap and show that synthetic pretraining remains beneficial for adaptation to OTA data. CorteXforge provides a practical foundation for reproducible RF dataset generation and future research on domain generalization.

arXiv:2610.26992v1 Announce Type: new Abstract: Split Federated Learning (SFL) has emerged as a promising paradigm for training large-scale deep models on resource-constrained edge devices. Although asynchronous SFL alleviates the straggler bottleneck caused by system heterogeneity, it inevitably introduces two coupled dimensions of inconsistency: horizontal inconsistency across clients and vertical inconsistency between clients and the server. These inconsistencies, further exacerbated by statistical heterogeneity, result in biased activation representations, model divergence, and severe client drift. To address these challenges, we propose CoASFL, an inconsistency-aware asynchronous SFL framework that incorporates a dynamic activation merging mechanism and a consistency-aware model aggregation mechanism. Specifically, CoASFL constructs more consistent activation sequences from heterogeneous clients to alleviate horizontal inconsistency, and dynamically adjusts aggregation weights according to client participation frequencies and progress gaps to mitigate vertical inconsistency. By jointly coordinating activation-level and model-level consistency, CoASFL effectively suppresses inconsistency propagation during asynchronous training. Extensive experiments on an 80-device heterogeneous edge testbed demonstrate that CoASFL consistently outperforms state-of-the-art SFL approaches, accelerating training by 1.61$\times$ to 3.74$\times$ and improving final model accuracy by up to 3.26\% under heterogeneous scenarios.

arXiv:2610.26979v1 Announce Type: new Abstract: Latent world models let an agent plan in latent space. The planner searches for an action sequence that minimizes a cost, and that cost is often the $\ell_2$ distance between the predicted terminal latent and the goal latent. The latent, however, is partly noise: the regularizer that prevents collapse during world model training promotes variance in the directions carrying no signal. We show that the same regularizer also supplies the structure to prune that noise in the latent. SIGReg drives the latent marginal to a standard Gaussian at every step, and assuming further that the latent sequence is a Gauss-Markov process, the transition is linear with its covariance pinned by the map itself, $z' \mid z \sim \mathcal{N}(Az,\, I - AA^\top)$. Fitting the state dynamics $A$ therefore yields the covariance at no additional cost, and in its eigenbasis each latent direction carries its own uncertainty. Furthermore, constraining $A$ to be a normal matrix fixes that basis across timesteps, so one eigenbasis measures the uncertainty over an arbitrary number of steps and serves as a stable basis to compute the planning cost on. We then restrict the $\ell_2$ cost to the $k$-dimensional subspace the state dynamics carry forward with the least uncertainty. The correction is post hoc: the encoder, the predictor, the rollout, and the planner are all left untouched, and only a single constrained matrix, $A$, is fit. We evaluate across six environments and show large gains on the 2D navigation tasks, TwoRoom and PointMaze, raising success rate over the plain $\ell_2$ cost by up to $+54.7$ points under a harder planning setting. Code is available at https://github.com/yjang43/lp2.

Health & Bioscience

A model developed by researchers at MIT and Boston Children's Hospital adjusts scans on the fly to track fetal movement, potentially sparing families repeat hospital visits.

New research can help AI models understand crystalline materials in 3D and reason about their properties.

General Science

The 18th annual Kendall Square Association Annual Meeting explored how new technologies could be a force for shared prosperity in society.

MIT's Center for Transportation and Logistics finds sustainability commitments are strong, but governance gaps and external disruptions prevent execution.