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John Michael Ong’echa
Affiliation : Kenya Medical Research Institute · Kenyatta University
- 72Publications (affiliation in Kenya)
Research profile
John Michael Ong’echa has 72 indexed publications (2003–2025). Their work appears mainly in “Infection and Immunity”, “Malaria Journal” and “BMC Infectious Diseases”. Their most cited article, “Severe Malarial Anemia: Innate Immunity and Pathogenesis” (2011), has been cited 316 times. 5 of these publications date from the last three years of activity. Their work is co-authored with at least 12 researchers, including institutions in United States, United Kingdom, Netherlands, Germany.
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Create my free profile Add my publicationsPublications (72)
- Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi
- Safety of RTS,S/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study
- Viral and host factors drive a type 1 Epstein–Barr virus spontaneous lytic phenotype
- Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
- Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar
- Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning
- Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria
- Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response
- Low Complexity of Infection Is Associated With Molecular Persistence of Plasmodium falciparum in Kenya and Tanzania
- Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma
- A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
- KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection
- Understanding the benefits and burdens associated with a malaria human infection study in Kenya: experiences of study volunteers and other stakeholders
- A New Hope for CD56negCD16pos NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases
- Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma
- Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma
- The whole-genome landscape of Burkitt lymphoma subtypes
- A cross-sectional analysis of factors associated with detection of oncogenic human papillomavirus in human immunodeficiency virus-infected and uninfected Kenyan women
- Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling
- Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
- Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region
- Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum
- Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas
- Malaria, mental disorders, immunity and their inter-relationships - A cross sectional study in a household population in a health and demographic surveillance site in Kenya
- Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactions
- Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
- Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
- Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
- Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma
- High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells
- CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia
- Malaria and mental disorder: a population study in an area endemic for malaria in Kenya
- Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya
- Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study
- Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation
- Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation
- Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study
- Prevalence of malaria parasites in adults and its determinants in malaria endemic area of Kisumu County, Kenya
- Common mental disorder in Nyanza province, Kenya in 2013 and its associated risk factors –an assessment of change since 2004, using a repeat household survey in a demographic surveillance site
- Tedium vitae, death wishes, suicidal ideation and attempts in Kenya-prevalence and risk factors
- Adult Psychotic Symptoms, Their Associated Risk Factors and Changes in Prevalence in Men and Women Over a Decade in a Poor Rural District of Kenya
- Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study
- Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
- Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia
- Variation in exposure to Anopheles gambiae salivary gland peptide (gSG6-P1) across different malaria transmission settings in the western Kenya highlands
- Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands
- Relationship between inflammatory mediator patterns and anemia in HIV‐1 positive and exposed children with Plasmodium falciparum malaria
- Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
- Reduced systemic bicyclo‐prostaglandin‐E2 and cyclooxygenase‐2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia
- Severe Malarial Anemia: Innate Immunity and Pathogenesis
- Identification of Inflammatory Biomarkers for Pediatric Malarial Anemia Severity Using Novel Statistical Methods
- Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
- Functional Promoter Haplotypes of Interleukin-18 Condition Susceptibility to Severe Malarial Anemia and Childhood Mortality
- Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
- Bacteremia in Kenyan Children Presenting with Malaria
- Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV‐1
- Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area
- MIF(Macrophage Migration Inhibitory Factor) Promoter Polymorphisms and Susceptibility to Severe Malarial Anemia
- Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism
- A Novel Functional Variant in the Stem Cell Growth Factor Promoter Protects against Severe Malarial Anemia
- Suppression of a Novel Hematopoietic Mediator in Children with Severe Malarial Anemia
- Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production
- Polymorphic Variability in the Interleukin (IL)–1β Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL‐1β Production
- Increased circulating interleukin (IL)-23 in children with malarial anemia: In vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10
- Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
- PARASITEMIA, ANEMIA, AND MALARIAL ANEMIA IN INFANTS AND YOUNG CHILDREN IN A RURAL HOLOENDEMIC PLASMODIUM FALCIPARUM TRANSMISSION AREA
- Acquisition of Hemozoin by Monocytes Down-Regulates Interleukin-12 p40 (IL-12p40) Transcripts and Circulating IL-12p70 through an IL-10-Dependent Mechanism: In Vivo and In Vitro Findings in Severe Malarial Anemia
- Role of Monocyte-Acquired Hemozoin in Suppression of Macrophage Migration Inhibitory Factor in Children with Severe Malarial Anemia
- ASSOCIATION OF FCγ RECEPTOR IIA (CD32) POLYMORPHISM WITH MALARIAL ANEMIA AND HIGH-DENSITY PARASITEMIA IN INFANTS AND YOUNG CHILDREN
- A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria
- Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-α regulation and viral replication
- ASSOCIATION OF INTERFERON-γ RESPONSES TO PRE-ERYTHROCYTIC STAGE VACCINE CANDIDATE ANTIGENS OF PLASMODIUM FALCIPARUM IN YOUNG KENYAN CHILDREN WITH IMPROVED HEMOGLOBIN LEVELS: XV. ASEMBO BAY COHORT PROJECT
Publication venues
- Infection and Immunity × 6
- Malaria Journal × 5
- BMC Infectious Diseases × 5
- The Journal of Infectious Diseases × 3
- EBioMedicine × 3
- American Journal of Hematology × 3
Publications per year
- 20252
- 20233
- 20225
- 20213
- 20203
- 20196
- 20183
- 20178
- 20164
- 20154
Collaborations
Partner institutions : KEMRI-Wellcome Trust Research Programme · University of New Mexico · University of Pittsburgh · Maseno University · Wellcome Trust
Co-authors’ countries : United States · United Kingdom · Netherlands · Germany
Co-authors
- Douglas Jay Perkins
- Collins Ouma
- Tom Were
- JOHN M. VULULE
- Evans O Raballah
- Bernhards Ragama Ogutu
- Samuel B. Anyona
- Cliff I. Oduor
- Juliana A. Otieno
- Raymond Omollo
- MICHAEL F. OTIENO
- Caleb Joseph Othieno
Bibliographic data from OpenAlex (open database).
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