Accueil › Annuaire des chercheurs › John Michael Ong’echa
John Michael Ong’echa
Affiliation : Kenya Medical Research Institute · Kenyatta University
- 72Publications (affiliation kényane)
Profil de recherche
John Michael Ong’echa compte 72 publications référencées (2003–2025). Ses travaux paraissent principalement dans « Infection and Immunity », « Malaria Journal » et « BMC Infectious Diseases ». Son article le plus cité, « Severe Malarial Anemia: Innate Immunity and Pathogenesis » (2011), a été cité 316 fois. 5 de ces publications datent des trois dernières années d’activité. Ses travaux sont cosignés avec au moins 12 chercheurs, notamment dans des établissements de États-Unis, Royaume-Uni, Pays-Bas, Allemagne.
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- Effectiveness of the RTS,S/AS01E malaria vaccine in a real-world setting over 1 year of follow-up after the three-dose primary schedule: an interim analysis of a phase 4 study in Ghana, Kenya, and Malawi
- Safety of RTS,S/AS01E malaria vaccine up to 1 year after the third dose in Ghana, Kenya, and Malawi (EPI-MAL-003): a phase 4 cohort event monitoring study
- Viral and host factors drive a type 1 Epstein–Barr virus spontaneous lytic phenotype
- Endemic Burkitt lymphoma avatar mouse models for exploring inter-patient tumor variation and testing targeted therapies
- Strong isolation by distance and evidence of population microstructure reflect ongoing Plasmodium falciparum transmission in Zanzibar
- Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning
- Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria
- Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response
- Low Complexity of Infection Is Associated With Molecular Persistence of Plasmodium falciparum in Kenya and Tanzania
- Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma
- A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
- KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection
- Understanding the benefits and burdens associated with a malaria human infection study in Kenya: experiences of study volunteers and other stakeholders
- A New Hope for CD56negCD16pos NK Cells as Unconventional Cytotoxic Mediators: An Adaptation to Chronic Diseases
- Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma
- Kaposi Sarcoma-Associated Herpesvirus Infection and Endemic Burkitt Lymphoma
- The whole-genome landscape of Burkitt lymphoma subtypes
- A cross-sectional analysis of factors associated with detection of oncogenic human papillomavirus in human immunodeficiency virus-infected and uninfected Kenyan women
- Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling
- Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
- Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region
- Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum
- Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas
- Malaria, mental disorders, immunity and their inter-relationships - A cross sectional study in a household population in a health and demographic surveillance site in Kenya
- Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactions
- Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
- Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma
- Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
- Human and Epstein-Barr Virus miRNA Profiling as Predictive Biomarkers for Endemic Burkitt Lymphoma
- High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells
- CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia
- Malaria and mental disorder: a population study in an area endemic for malaria in Kenya
- Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya
- Factors influencing survival among Kenyan children diagnosed with endemic Burkitt lymphoma between 2003 and 2011: A historical cohort study
- Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation
- Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation
- Regulatory T Cells in Endemic Burkitt Lymphoma Patients Are Associated with Poor Outcomes: A Prospective, Longitudinal Study
- Prevalence of malaria parasites in adults and its determinants in malaria endemic area of Kisumu County, Kenya
- Common mental disorder in Nyanza province, Kenya in 2013 and its associated risk factors –an assessment of change since 2004, using a repeat household survey in a demographic surveillance site
- Tedium vitae, death wishes, suicidal ideation and attempts in Kenya-prevalence and risk factors
- Adult Psychotic Symptoms, Their Associated Risk Factors and Changes in Prevalence in Men and Women Over a Decade in a Poor Rural District of Kenya
- Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study
- Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels
- Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia
- Variation in exposure to Anopheles gambiae salivary gland peptide (gSG6-P1) across different malaria transmission settings in the western Kenya highlands
- Marked variation in MSP-119 antibody responses to malaria in western Kenyan highlands
- Relationship between inflammatory mediator patterns and anemia in HIV‐1 positive and exposed children with Plasmodium falciparum malaria
- Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality
- Reduced systemic bicyclo‐prostaglandin‐E2 and cyclooxygenase‐2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia
- Severe Malarial Anemia: Innate Immunity and Pathogenesis
- Identification of Inflammatory Biomarkers for Pediatric Malarial Anemia Severity Using Novel Statistical Methods
- Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children
- Functional Promoter Haplotypes of Interleukin-18 Condition Susceptibility to Severe Malarial Anemia and Childhood Mortality
- Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria
- Bacteremia in Kenyan Children Presenting with Malaria
- Hematological predictors of increased severe anemia in Kenyan children coinfected with Plasmodium falciparum and HIV‐1
- Clinical predictors of severe malarial anaemia in a holoendemic Plasmodium falciparum transmission area
- MIF(Macrophage Migration Inhibitory Factor) Promoter Polymorphisms and Susceptibility to Severe Malarial Anemia
- Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism
- A Novel Functional Variant in the Stem Cell Growth Factor Promoter Protects against Severe Malarial Anemia
- Suppression of a Novel Hematopoietic Mediator in Children with Severe Malarial Anemia
- Haplotypes of IL-10 promoter variants are associated with susceptibility to severe malarial anemia and functional changes in IL-10 production
- Polymorphic Variability in the Interleukin (IL)–1β Promoter Conditions Susceptibility to Severe Malarial Anemia and Functional Changes in IL‐1β Production
- Increased circulating interleukin (IL)-23 in children with malarial anemia: In vivo and in vitro relationship with co-regulatory cytokines IL-12 and IL-10
- Increased severe anemia in HIV-1-exposed and HIV-1-positive infants and children during acute malaria
- PARASITEMIA, ANEMIA, AND MALARIAL ANEMIA IN INFANTS AND YOUNG CHILDREN IN A RURAL HOLOENDEMIC PLASMODIUM FALCIPARUM TRANSMISSION AREA
- Acquisition of Hemozoin by Monocytes Down-Regulates Interleukin-12 p40 (IL-12p40) Transcripts and Circulating IL-12p70 through an IL-10-Dependent Mechanism: In Vivo and In Vitro Findings in Severe Malarial Anemia
- Role of Monocyte-Acquired Hemozoin in Suppression of Macrophage Migration Inhibitory Factor in Children with Severe Malarial Anemia
- ASSOCIATION OF FCγ RECEPTOR IIA (CD32) POLYMORPHISM WITH MALARIAL ANEMIA AND HIGH-DENSITY PARASITEMIA IN INFANTS AND YOUNG CHILDREN
- A macrophage migration inhibitory factor promoter polymorphism is associated with high-density parasitemia in children with malaria
- Stage-specific effects of Plasmodium falciparum-derived hemozoin on blood mononuclear cell TNF-α regulation and viral replication
- ASSOCIATION OF INTERFERON-γ RESPONSES TO PRE-ERYTHROCYTIC STAGE VACCINE CANDIDATE ANTIGENS OF PLASMODIUM FALCIPARUM IN YOUNG KENYAN CHILDREN WITH IMPROVED HEMOGLOBIN LEVELS: XV. ASEMBO BAY COHORT PROJECT
Revues de publication
- Infection and Immunity × 6
- Malaria Journal × 5
- BMC Infectious Diseases × 5
- The Journal of Infectious Diseases × 3
- EBioMedicine × 3
- American Journal of Hematology × 3
Publications par année
- 20252
- 20233
- 20225
- 20213
- 20203
- 20196
- 20183
- 20178
- 20164
- 20154
Collaborations
Établissements partenaires : KEMRI-Wellcome Trust Research Programme · University of New Mexico · University of Pittsburgh · Maseno University · Wellcome Trust
Pays des co-auteurs : États-Unis · Royaume-Uni · Pays-Bas · Allemagne
Co-auteurs
- Douglas Jay Perkins
- Collins Ouma
- Tom Were
- JOHN M. VULULE
- Evans O Raballah
- Bernhards Ragama Ogutu
- Samuel B. Anyona
- Cliff I. Oduor
- Juliana A. Otieno
- Raymond Omollo
- MICHAEL F. OTIENO
- Caleb Joseph Othieno
Données bibliographiques issues d’OpenAlex (base ouverte).
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