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Kevin Marsh
Affiliation : Kenya Medical Research Institute · KEMRI-Wellcome Trust Research Programme
- 316Publications (affiliation kényane)
Profil de recherche
Kevin Marsh compte 316 publications référencées (2011–2025). Ses travaux paraissent principalement dans « PLoS ONE », « BMC Medicine » et « Malaria Journal ». Son article le plus cité, « Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing » (2012), a été cité 486 fois. Ses travaux sont cosignés avec au moins 12 chercheurs, notamment dans des établissements de Royaume-Uni, Ouganda, Tanzanie, Ghana.
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- Plasmodium falciparum reticulocyte-binding homologues are targets of human inhibitory antibodies and play a role in immune evasion
- Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria
- Controlled human malaria infection (CHMI) outcomes in Kenyan adults is associated with prior history of malaria exposure and anti-schizont antibody response
- An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
- Malaria protection due to sickle haemoglobin depends on parasite genotype
- Understanding the benefits and burdens associated with a malaria human infection study in Kenya: experiences of study volunteers and other stakeholders
- Identifying prognostic factors of severe metabolic acidosis and uraemia in African children with severe falciparum malaria: a secondary analysis of a randomized trial
- The remaining unknowns: a mixed methods study of the current and global health research priorities for COVID-19
- Funding and COVID-19 research priorities - are the research needs for Africa being met?
- Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania
- Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study
- IgM in human immunity to Plasmodium falciparum malaria
- Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya
- Effect of 10-valent pneumococcal conjugate vaccine on the incidence of radiologically-confirmed pneumonia and clinically-defined pneumonia in Kenyan children: an interrupted time-series analysis
- Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort
- Gametocyte carriage in an era of changing malaria epidemiology: A 19-year analysis of a malaria longitudinal cohort
- A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01E on blood stage immunity in young Kenyan children
- Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection
- Exploring Plasmodium falciparum Var Gene Expression to Assess Host Selection Pressure on Parasites During Infancy
- Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
- KILchip v1.0: A Novel Plasmodium falciparum Merozoite Protein Microarray to Facilitate Malaria Vaccine Candidate Prioritization
- Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity
- Resistance to malaria through structural variation of red blood cell invasion receptors
- Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia
- Adaptation of Plasmodium falciparum to its transmission environment
- Declining Malaria Transmission Differentially Impacts the Maintenance of Humoral Immunity to Plasmodium falciparum in Children
- Plasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure
- Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children
- Age, Spatial, and Temporal Variations in Hospital Admissions with Malaria in Kilifi County, Kenya: A 25-Year Longitudinal Observational Study
- Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast
- Targets and Mechanisms Associated with Protection from Severe Plasmodium falciparum Malaria in Kenyan Children
- Differing rates of antibody acquisition to merozoite antigens in malaria: implications for immunity and surveillance
- Cord blood IgG and the risk of severe Plasmodium falciparum malaria in the first year of life
- A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies
- Mind the gap: jumping from vaccine licensure to routine use
- The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum – an epidemiological “natural experiment”
- Changes in Serological Immunology Measures in UK and Kenyan Adults Post-controlled Human Malaria Infection
- Prevalence, causes, and behavioral and emotional comorbidities of acute symptomatic seizures in Africa: A critical review
- Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population
- Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine
- Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial
- Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria
- A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
- Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults
- Malaria eradication and elimination: views on how to translate a vision into reality
- Lessons learnt from the first controlled human malaria infection study conducted in Nairobi, Kenya
- Increased sample volume and use of quantitative reverse-transcription PCR can improve prediction of liver-to-blood inoculum size in controlled human malaria infection studies
- Genetic determinants of anti-malarial acquired immunity in a large multi-centre study
- Multiple clinical episodes of Plasmodium falciparum malaria in a low transmission intensity setting: exposure versus immunity
- Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya
- Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models
- Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity
- Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria
- Reappraisal of known malaria resistance loci in a large multicenter study
- New antigens for a multicomponent blood-stage malaria vaccine
- A micro-epidemiological analysis of febrile malaria in Coastal Kenya showing hotspots within hotspots
- Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injection
- Plasmodium falciparum Malaria in Children Aged 0-2 Years: The Role of Foetal Haemoglobin and Maternal Antibodies to Two Asexual Malaria Vaccine Candidates (MSP3 and GLURP)
- Whole-Genome Scans Provide Evidence of Adaptive Evolution in Malawian Plasmodium falciparum Isolates
- Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines
- Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya
- A Genome Wide Association Study of Plasmodium falciparum Susceptibility to 22 Antimalarial Drugs in Kenya
- Controlled human malaria infection in Kenyan adults: A safe model that could accelerate assessment of novel drugs and vaccines in malaria endemic populations
- Avidity of Anti-Circumsporozoite Antibodies following Vaccination with RTS,S/AS01E in Young Children
- Plasmodium falciparumantigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria
- CD4+ T Cell Responses to the Plasmodium falciparum Erythrocyte Membrane Protein 1 in Children with Mild Malaria
- Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure
- Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations
- A Library of Functional Recombinant Cell-surface and Secreted P. falciparum Merozoite Proteins
- A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria
- Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya
- Breadth of Anti-Merozoite Antibody Responses Is Associated With the Genetic Diversity of Asymptomatic Plasmodium falciparum Infections and Protection Against Clinical Malaria
- The Ratio of Monocytes to Lymphocytes in Peripheral Blood Correlates with Increased Susceptibility to Clinical Malaria in Kenyan Children
- Erythrocyte-Binding Antigens ofPlasmodium falciparumAre Targets of Human Inhibitory Antibodies and Function To Evade Naturally Acquired Immunity
- Plasmodium falciparum var Gene Expression Homogeneity as a Marker of the Host-Parasite Relationship under Different Levels of Naturally Acquired Immunity to Malaria
- Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data
- Antibodies to Polymorphic Invasion-Inhibitory and Non-Inhibitory Epitopes of Plasmodium falciparum Apical Membrane Antigen 1 in Human Malaria
- Phenotypic and Functional Profiling of CD4 T Cell Compartment in Distinct Populations of Healthy Adults with Different Antigenic Exposure
- Analysis of Antibodies to Newly Described Plasmodium falciparum Merozoite Antigens Supports MSPDBL2 as a Predicted Target of Naturally Acquired Immunity
- Plasmodium falciparum Infection Patterns Since Birth and Risk of Severe Malaria: A Nested Case-Control Study in Children on the Coast of Kenya
- Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
- Profile: The Kilifi Health and Demographic Surveillance System (KHDSS)
- Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion
- Targets of antibodies against Plasmodium falciparum–infected erythrocytes in malaria immunity
- Wind direction and proximity to larval sites determines malaria risk in Kilifi District in Kenya
- Prognostic Indicators of Life-Threatening Malaria Are Associated with Distinct Parasite Variant Antigen Profiles
- The Changing Limits and Incidence of Malaria in Africa
- Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children
- Naturally acquired immune responses against Plasmodium falciparum sporozoites and liver infection
- Estimating Individual Exposure to Malaria Using Local Prevalence of Malaria Infection in the Field
- Lack of Avidity Maturation of Merozoite Antigen-Specific Antibodies with Increasing Exposure to Plasmodium falciparum amongst Children and Adults Exposed to Endemic Malaria in Kenya
- Genome Wide Adaptations of Plasmodium falciparum in Response to Lumefantrine Selective Drug Pressure
- T-Cell Responses to the DBLα-Tag, a Short Semi-Conserved Region of the Plasmodium falciparum Membrane Erythrocyte Protein 1
- Mortality in Sickle Cell Anemia in Africa: A Prospective Cohort Study in Tanzania
- Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
- The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
- Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5–17 months in Kenya and Tanzania: a randomised controlled trial
- Declining Responsiveness of Plasmodium falciparum Infections to Artemisinin-Based Combination Treatments on the Kenyan Coast
- Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome
- A Molecular Epidemiological Study of var Gene Diversity to Characterize the Reservoir of Plasmodium falciparum in Humans in Africa
Revues de publication
- PLoS ONE × 16
- BMC Medicine × 8
- Malaria Journal × 7
- Nature Communications × 5
- Wellcome Open Research × 4
- Frontiers in Immunology × 3
Publications par année
- 20251
- 20222
- 20214
- 20202
- 201910
- 20182
- 20176
- 201612
- 201513
- 201414
Collaborations
Établissements partenaires : University of Oxford · Wellcome Trust · John Radcliffe Hospital · London School of Hygiene & Tropical Medicine · University College London
Pays des co-auteurs : Royaume-Uni · Ouganda · Tanzanie · Ghana
Co-auteurs
- Thomas Neil Williams
- Philip Bejon
- Norbert M. Peshu
- Charles R. J. C. Newton
- Robert William Snow
- Brett S Lowe
- Faith H. A. Osier
- Peter C. Bull
- Tabitha Mwangi
- Greg Fegan
- James Alexander Berkley
- Patricia Njuguna
Données bibliographiques issues d’OpenAlex (base ouverte).
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