Accueil › Annuaire des chercheurs › Laurent Abel
Laurent Abel
Affiliation : Hôpital Necker-Enfants Malades · Inserm · Université Paris Cité · Human Genetic of Infectious Diseases · Institut des Maladies Génétiques Imagine · Université Paris Descartes
- 49Publications (affiliation française)
- 731Publications au total
- 69210Citations
- 135Indice h
Profil de recherche
Laurent Abel compte 49 publications référencées (2004–2026). Ses travaux paraissent principalement dans « The Journal of Experimental Medicine », « Journal of Clinical Immunology » et « Science Immunology ». Son article le plus cité, « Deep Dermatophytosis and Inherited CARD9 Deficiency » (2013), a été cité 392 fois. 8 de ces publications datent des trois dernières années d’activité. Ses travaux sont cosignés avec au moins 12 chercheurs, notamment dans des établissements de États-Unis, Italie, Espagne, Belgique.
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Créer mon profil gratuit Ajouter mes publicationsDomaines de recherche
- Immunodeficiency and Autoimmune Disorders
- Genetic Associations and Epidemiology
- interferon and immune responses
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
Publications (49)
- Human LFA-1 governs T cell immune surveillance of the skin
- Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis
- Auto-antibodies neutralizing type I interferons in ~10% of Moroccan patients with life-threatening COVID-19
- High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies
- High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies
- Human LY9 governs CD4 + T cell IFN-γ immunity to Mycobacterium tuberculosis
- Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2
- A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure
- Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
- Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia
- Mendelian Susceptibility to Mycobacterial Disease (MSMD): Clinical, Immunological, and Genetic Features of 22 Patients from 15 Moroccan Kindreds
- Mendelian susceptibility to mycobacterial disease: an overview
- Studying severe long COVID to understand post-infectious disorders beyond COVID-19
- Human T-bet governs the generation of a distinct subset of CD11c high CD21 low B cells
- Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency
- Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis
- Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance
- Inherited GATA2 Deficiency Is Dominant by Haploinsufficiency and Displays Incomplete Clinical Penetrance
- High Th2 cytokine levels and upper airway inflammation in human inherited T-bet deficiency
- Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to multiple infectious agents
- Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
- Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis
- Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Morocco
- A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
- Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
- Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons
- Human Genetics of Tuberculosis of the Nervous System
- Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency
- Mycobacterial disease in patients with chronic granulomatous disease: A retrospective analysis of 71 cases
- Dual T cell– and B cell–intrinsic deficiency in humans with biallelic RLTPR mutations
- Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage
- A genome-wide association study of pulmonary tuberculosis in Morocco
- Utility of the QuantiFERON®-TB Gold In-Tube assay for the diagnosis of tuberculosis in Moroccan children
- Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
- Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
- Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both
- Pott's disease in Moroccan children: clinical features and investigation of the interleukin-12/interferon-γ pathway
- Human genetics of tuberculosis: a long and winding road
- Association Study of Genes Controlling IL-12-dependent IFN-γ Immunity: STAT4 Alleles Increase Risk of Pulmonary Tuberculosis in Morocco
- Chronic Granulomatous Disease in Morocco: Genetic, Immunological, and Clinical Features of 12 Patients from 10 Kindreds
- Deep Dermatophytosis and Inherited CARD9 Deficiency
- Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor β1 Deficiency
- Primary Immunodeficiency Diseases Worldwide: More Common than Generally Thought
- IL-12Rβ1 Deficiency in Two of Fifty Children with Severe Tuberculosis from Iran, Morocco, and Turkey
- Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients
- Primary immunodeficiencies of protective immunity to primary infections
- X-linked susceptibility to mycobacteria is caused by mutations in NEMO impairing CD40-dependent IL-12 production
- An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults
- Association ofIL12RB1Polymorphisms with Pulmonary Tuberculosis in Adults in Morocco
Revues de publication
- The Journal of Experimental Medicine × 9
- Journal of Clinical Immunology × 6
- Science Immunology × 4
- Proceedings of the National Academy of Sciences × 4
- Nature Medicine × 2
- PLoS ONE × 2
Publications par année
- 20265
- 20253
- 20234
- 20224
- 20214
- 20201
- 20192
- 20183
- 20171
- 20166
Collaborations
Établissements partenaires : Rockefeller University · Assistance Publique – Hôpitaux de Paris · Howard Hughes Medical Institute · Sorbonne Paris Cité · Institut Necker Enfants Malades
Pays des co-auteurs : États-Unis · Italie · Espagne · Belgique
Co-auteurs
- Jean‐Laurent Casanova
- Stéphanie Boisson‐Dupuis
- Jacinta C. Bustamante
- Anne Puel
- Capucine Pïcard
- Aurélie Cobat
- Emmanuelle Jouanguy
- Caroline Deswarte
- Mélanie Migaud
- Jérémie Rosain
- Vivien Béziat
- Bertrand Boisson
Données bibliographiques issues d’OpenAlex (base ouverte).
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