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Gérard Lizard
Affiliation : Centre National de la Recherche Scientifique · Inserm · Université de Bourgogne · Laboratoire Interdisciplinaire Carnot de Bourgogne · Laboratoire Bio-peroxIL · Université Bourgogne Europe
- 140Publications (affiliation in France)
- 443Total publications
- 27297Citations
- 68h-index
Research profile
Gérard Lizard has 140 indexed publications (2017–2026). Their work appears mainly in “Cells”, “The Journal of Steroid Biochemistry and Molecular Biology” and “Advances in experimental medicine and biology”. Their most cited article, “Lipid Biomarkers in Alzheimer's Disease” (2017), has been cited 170 times. 29 of these publications date from the last three years of activity. Their work is co-authored with at least 12 researchers, including institutions in Tunisia, Morocco, Ireland, Lebanon.
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Create my free profile Add my publicationsResearch areas
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Cell death mechanisms and regulation
- Atherosclerosis and Cardiovascular Diseases
- Phytochemicals and Antioxidant Activities
Publications (140)
- Synergistic Anticancer Activity of Annona muricata Leaf Extract and Cisplatin in 4T1 Triple-Negative Breast Cancer Cells
- Exploring the Dual Role of Resveratrol in N2a Neuronal Cells: Mechanisms, Benefits, and Future Directions
- 7-ketocholesterol as a theranostic target: Potential applications and future perspectives
- Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia
- Erythrocyte trans fatty acid accumulation in elderly sarcopenic patients: biochemical evidence for oxidative stress-driven cis-trans isomerization of membrane lipids
- Intracerebroventricular delivery of an ODN peptide analog protects dopaminergic neurons and modulates miRNA expression in a mouse model of Parkinson’s disease
- Oxysterols, age-related-diseases and nutritherapy: Focus on 7-ketocholesterol and 7β-hydroxycholesterol
- Enhancing human gut health: Global innovations in dysbiosis management
- Arginase Activity Inhibition With Thymoquinone Induces a Hybrid Type of Cell‐Death in MDA‐MB‐231 Cell Line
- Potential contribution of oxysterols and cholestanol in the vascular inflammatory process occurring in patients with Behcet’s disease
- Synthesis and structural characterization of coumarin–hydrazone derivatives as antiplatelet agents: in vitro and in silico evaluation of activity and toxicity
- Analytical subcellular fractionation of microglial BV-2 cells with peroxisomal beta-oxidation defect
- Corrigendum to “Lipid droplets dependent or independent cytoprotective activities of unsaturated fatty acids, Lorenzo’s oil and sulfo-N-succinimidyl oleate on 7-ketocholesterol-induced oxidative stress, organelle dysfunction and cell death on 158N and ARPE-19 cells: Cell targets and benefits of sulfo-N-succinimidyl oleate” [Curr. Res. Biotechnol. 7 (2024) 100195]
- Implication of cholesterol oxidation products (oxysterols) in neurodegeneration: cytoprotective activities of polyphenols, tocopherols and fatty acids, representative nutrients of the Mediterranean diet
- Protective and neurotrophic effects of OctaDecaNeuropeptide (ODN) in in vitro and in vivo models of neurodegenerative diseases
- Natural guardians as radioprotective complements in oncological therapy: A review
- Benefits of rutin on mitochondrial function and inflammation in an aluminum-induced neurotoxicity rat model: Potential interest for the prevention of neurodegeneration
- Current advances in phytosterol free forms and esters: Classification, biosynthesis, chemistry, and detection
- Anthocyanins - dietary natural products with a variety of bioactivities for the promotion of human and animal health
- Characterization of Silybum marianum and Silybum eburneum seed oils: Phytochemical profiles and antioxidant properties supporting important nutritional interests
- Cytoprotective effects of α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, oleic acid and α-tocopherol on 7-ketocholesterol – Induced oxiapoptophagy: Major roles of PI3-K / PDK-1 / Akt signaling pathway and glutathione peroxidase activity in cell rescue
- Tunisian Silybum Species: Important Sources of Polyphenols, Organic Acids, Minerals, and Proteins across Various Plant Organs
- Lipid droplets dependent or independent cytoprotective activities of unsaturated fatty acids, Lorenzo’s oil and sulfo-N-succinimidyl oleate on 7-ketocholesterol-induced oxidative stress, organelle dysfunction and cell death on 158N and ARPE-19 cells: Cell targets and benefits of sulfo-N-succinimidyl oleate
- Octadecaneuropeptide, ODN, Promotes Cell Survival against 6-OHDA-Induced Oxidative Stress and Apoptosis by Modulating the Expression of miR-34b, miR-29a, and miR-21in Cultured Astrocytes
- In vitro immunotoxicity effects of carbendazim were inhibited by n-acetylcysteine in microglial BV-2 cells
- First International Symposium “Valorization of the Mediterranean Vegetal Biodiversity: Nutritional, Therapeutic and Biotechnologic Aspects”, 25–26 April 2024, Marrakech, Morocco [Meeting Report]
- Prevention of Oxysterol-Induced Oxiapoptophagy with Mediterranean Oils: Nutritherapeutic Approach of Age-Related Diseases
- Octadecaneuropeptide (ODN) Mediated miRNA Regulation: A Novel Scientific Approach to Protect against Cell Death and Neuroinflammation in a Cellular Model of Neurodegenerative Disease
- Neuroprotective Effects of the Neuropeptide ODN against Inflammatory, Oxidative Stress, and Neurodegenerative Disorders Induced by Obesity
- 7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes
- Effects of polyphenols and their metabolites on age-related diseases
- Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in Acox1−/− and Wild-Type BV-2 Microglial Cells
- Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects
- Characterization of Cell Death Induced by Imine Analogs of Trans-Resveratrol: Induction of Mitochondrial Dysfunction and Overproduction of Reactive Oxygen Species Leading to, or Not, Apoptosis without the Increase in the S-Phase of the Cell Cycle
- Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers
- In Vitro Evaluation of the Effects of 7-Ketocholesterol and 7β-Hydroxycholesterol on the Peroxisomal Status: Prevention of Peroxisomal Damages and Concept of Pexotherapy
- Thymus atlanticus: A Source of Nutrients with Numerous Health Benefits and Important Therapeutic Potential for Age-Related Diseases
- Chemical and Biochemical Features of Spinasterol and Schottenol
- Modulatory effects of the addition of argan and olive oils on oxidative and nitrosative stress induced in Tetrahymena pyriformis
- Tunisian Silybum species: Potential source of phytochemicals, organic acids, minerals, and proteins across various plant organs
- Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in Vitro and in Vivo Models of Neurodegenerative Diseases
- Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases
- The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis
- Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications
- Cytoprotective activities of representative nutrients from the Mediterranean diet and of Mediterranean oils against 7-ketocholesterol- and 7β-hydroxycholesterol-induced cytotoxicity: Application to age-related diseases and civilization diseases
- Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy
- Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases
- Protective Effect of Nopal Cactus (Opuntia ficus-indica) Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver
- Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production
- Profiles of Fatty Acids, Polyphenols, Sterols, and Tocopherols and Scavenging Property of Mediterranean Oils: New Sources of Dietary Nutrients for the Prevention of Age-related Diseases
- Whole and Purified Aqueous Extracts of Nigella sativa L. Seeds Attenuate Apoptosis and the Overproduction of Reactive Oxygen Species Triggered by p53 Over-Expression in the Yeast Saccharomyces cerevisiae
- Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells
- Oxiapoptophagy in Age-Related Diseases. Comment on Ouyang et al. 7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells. Cells 2022, 11, 2882
- Pharmacological and Nutraceutical Activation of Rejuvenation, Geroprotection and Cytoprotection: Proofs of Concept
- AB1481 RedOx HOMEOSTASIS AND ANTIOXIDANT RESPONSE DEFENSE IN SKELETAL MUSCLE PERFORMANCE IN THE ELDERLY
- Oxysterols-induced oxidative stress, mitochondrial and peroxisomal dysfunctions: potential consequences on age-related diseases
- Analysis of the mitochondrial status of murine neuronal N2a cells treated with resveratrol and synthetic isomeric resveratrol analogs: aza-stilbenes
- Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases
- Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status
- 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19
- Antioxidant Properties and Cytoprotective Effect of Pistacia lentiscus L. Seed Oil against 7β-Hydroxycholesterol-Induced Toxicity in C2C12 Myoblasts: Reduction in Oxidative Stress, Mitochondrial and Peroxisomal Dysfunctions and Attenuation of Cell Death
- Oxysterols and multiple sclerosis: Physiopathology, evolutive biomarkers and therapeutic strategy
- Cholesterol Derivatives as Promising Anticancer Agents in Glioblastoma Metabolic Therapy
- Oxiapoptophagy: A type of cell death induced by some oxysterols
- Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases
- Comparison of chemical composition and biological activities of Algerian seed oils of Pistacia lentiscus L., Opuntia ficus indica (L.) mill. and Argania spinosa L. Skeels
- Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients
- Potential Involvement of Peroxisome in Multiple Sclerosis and Alzheimer’s Disease
- 7-Ketocholesterol- and 7β-Hydroxycholesterol-Induced Peroxisomal Disorders in Glial, Microglial and Neuronal Cells: Potential Role in Neurodegeneration
- Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil
- Cytoprotective and Neurotrophic Effects of Octadecaneuropeptide (ODN) in in vitro and in vivo Models of Neurodegenerative Diseases
- Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella Seed Oil) and Evaluation of their Antioxidant and Cytoprotective Activities
- 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity
- Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes
- Localisation of oxysterols at the sub-cellular level and in biological fluids
- Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol
- Flavonoids differentially modulate liver X receptors activity—Structure-function relationship analysis
- Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells
- Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles
- Correlation of trans fatty acids with the severity of coronary artery disease lesions
- Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin
- Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols
- Prevention of 7-ketocholesterol-induced side effects by natural compounds
- A microglial cell model for acyl-CoA oxidase 1 deficiency
- Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol
- Peroxisomal Acyl‐CoA Oxidase Type 1: Anti‐Inflammatory and Anti‐Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging
- Evaluation of Antioxidant, Anti-Inflammatory and Cytoprotective Properties of Ethanolic Mint Extracts from Algeria on 7-Ketocholesterol-Treated Murine RAW 264.7 Macrophages
- Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes
- The effect of oxysterols on nerve impulses
- Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0)
- Lipid Biomarkers in Alzheimer's Disease
- Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells
- Tunisian Milk Thistle: An Investigation of the Chemical Composition and the Characterization of Its Cold-Pressed Seed Oils
- Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N
- Benefits of Argan Oil on Human Health—May 4–6 2017, Errachidia, Morocco
- Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes
- Identification of long and very long chain fatty acids, plasmalogen-C16:0 and phytanic acid as new lipid biomarkers in Tunisian coronary artery disease patients
- Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides
- Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients
- Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells
Publication venues
- Cells × 8
- The Journal of Steroid Biochemistry and Molecular Biology × 8
- Advances in experimental medicine and biology × 6
- Biochimie × 5
- HAL × 5
- Antioxidants × 4
Publications per year
- 20266
- 202510
- 202413
- 202312
- 202216
- 20216
- 20208
- 20198
- 201811
- 201710
Collaborations
Partner institutions : Université Bourgogne Franche-Comté · University of Monastir · Tunis El Manar University · Centre des Sciences du Goût et de l'Alimentation · Université Hassan 1er
Co-authors’ countries : Tunisia · Morocco · Ireland · Lebanon
Co-authors
- Anne Véjux
- Thomas Nury
- Imen Ghzaiel
- Amira Zarrouk
- Mustapha Cherkaoui‐Malki
- Mohammad Hadi Samadi
- Pierre Andreoletti
- Norbert Latruffe
- Thibault Moreau
- Mohamed Ksila
- Aline Yammine
- Jean‐Marc Riedinger
Bibliographic data from OpenAlex (open database).
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